Switch-like Membrane Properties Computed from Classical-type Na+ and K+ Currents: A Neuronal Memory Device

The present computational study shows that switch-like membrane properties can be obtained from a model neuron with classical-type Na+ and K+ currents. The membrane potential can adopt two stable steady-state levels and transitions between the two levels may be triggered by positive or negative current stimuli. Thus, the neuron functions in analogy to the flip-flop devices used in computers. In the absence of stimulus input, the neuron may maintain either of the two stable potential levels for infinite durations. Thus, in contrast to plateau-potential generating neurons described earlier, it is suitable for long-term memory. chanisms underlying the switch-properties depend entirely on parameter values within the range measured from biological experiments: a relatively large "classical" Na+ current, with respect to K+ and leak currents, is required. It is hypothesized that similar switch-like membrane properties may be found among living neurons in the mammalian brain.