Title of article :
Does tumor growth follow a “universal law”?
Author/Authors :
Guiot، نويسنده , , Caterina and Degiorgis، نويسنده , , Piero Giorgio and Delsanto، نويسنده , , Pier Paolo and Gabriele، نويسنده , , Pietro and Deisboeck، نويسنده , , Thomas S.، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2003
Abstract :
A general model for the ontogenetic growth of living organisms has been recently proposed. Here we investigate the extension of this model to the growth of solid malignant tumors. A variety of in vitro and in vivo data are analysed and compared with the prediction of a “universal” law, relating properly rescaled tumor masses and tumor growth times. The results support the notion that tumor growth follows such a universal law. Several important implications of this finding are discussed, including its relevance for tumor metastasis and recurrence, cell turnover rates, angiogenesis and invasion.
Keywords :
Invasion , Tumor therapy , Tumor growth kinetics , Methametical modelling , Universal law , metastasis , Angiogenesis
Journal title :
Journal of Theoretical Biology
Journal title :
Journal of Theoretical Biology