Title of article
BDI-modelling of complex intracellular dynamics
Author/Authors
Jonker، نويسنده , , C.M. and Snoep، نويسنده , , J.L. and Treur، نويسنده , , FRANK J. and WESTERHOFF، نويسنده , , H.V. and Wijngaards، نويسنده , , W.C.A. Gelderblom، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
23
From page
1
To page
23
Abstract
A BDI-based continuous-time modelling approach for intracellular dynamics is presented. It is shown how temporalised BDI-models make it possible to model intracellular biochemical processes as decision processes. By abstracting from some of the details of the biochemical pathways, the model achieves understanding in nearly intuitive terms, without losing veracity: classical intentional state properties such as beliefs, desires and intentions are founded in reality through precise biochemical relations. In an extensive example, the complex regulation of Escherichia coli vis-à-vis lactose, glucose and oxygen is simulated as a discrete-state, continuous-time temporal decision manager. Thus a bridge is introduced between two different scientific areas: the area of BDI-modelling and the area of intracellular dynamics.
Keywords
Modelling of bacterial behaviour , Intentional , Continuous time , BDI-model , catabolite repression , regulation
Journal title
Journal of Theoretical Biology
Serial Year
2008
Journal title
Journal of Theoretical Biology
Record number
1539152
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