Title of article :
BDI-modelling of complex intracellular dynamics
Author/Authors :
Jonker، نويسنده , , C.M. and Snoep، نويسنده , , J.L. and Treur، نويسنده , , FRANK J. and WESTERHOFF، نويسنده , , H.V. and Wijngaards، نويسنده , , W.C.A. Gelderblom، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Pages :
23
From page :
1
To page :
23
Abstract :
A BDI-based continuous-time modelling approach for intracellular dynamics is presented. It is shown how temporalised BDI-models make it possible to model intracellular biochemical processes as decision processes. By abstracting from some of the details of the biochemical pathways, the model achieves understanding in nearly intuitive terms, without losing veracity: classical intentional state properties such as beliefs, desires and intentions are founded in reality through precise biochemical relations. In an extensive example, the complex regulation of Escherichia coli vis-à-vis lactose, glucose and oxygen is simulated as a discrete-state, continuous-time temporal decision manager. Thus a bridge is introduced between two different scientific areas: the area of BDI-modelling and the area of intracellular dynamics.
Keywords :
Modelling of bacterial behaviour , Intentional , Continuous time , BDI-model , catabolite repression , regulation
Journal title :
Journal of Theoretical Biology
Serial Year :
2008
Journal title :
Journal of Theoretical Biology
Record number :
1539152
Link To Document :
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