Global stability of a DS–DI epidemic model with age of infection

A model with differential susceptibility, differential infectivity (DS–DI), and age of infection is formulated in this paper. The susceptibles are divided into n groups according to their susceptibilities. The infectives are divided into m groups according to their infectivities. The total population size is assumed constant. Formula for the reproductive number is derived so that if the reproduction number is less than one, the infection-free equilibrium is locally stable, and unstable otherwise. Furthermore, if the reproductive number is less than one, the infection-free equilibrium is globally asymptotically stable. If the reproductive number is greater than one, it is shown that there exists a unique endemic equilibrium which is globally asymptotically stable. This result is obtained through a Lyapunov function.