Title of article
Synthesis and antihypertensive activity of novel 4-[1-(4-X-benzyl)-5-imidazolyl] dihydropyridines in rat
Author/Authors
Hadizadeh، F. نويسنده Biotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, I.R. Iran. , , Fatehi-Hassanabad، Z. نويسنده Department of Physiology and Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, I.R.Iran. , , Fatehi-Hassanabad، M. نويسنده Department of Physiology and Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, I.R.Iran. , , Beheshtizadeh، A. نويسنده Department of Medicinal Chemistry, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, I.R Iran. , , Nabati، F. نويسنده Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, I.R.Iran. ,
Issue Information
دوفصلنامه با شماره پیاپی 0 سال 2007
Pages
6
From page
87
To page
92
Abstract
A series of 1,4-dihydropyridine calcium channel blockers bearing 1-(4-X -benzyl)-5-imidazolyl substituent at 4 position (5a-e) (X=H, F) were synthesized and tested for antihypertensive activity in desoxycorticosterone acetate (DOCA)-induced hypertension in rats. Amlodipine was used as the standard dihydropyridine. All compounds tested showed lower antihypertensive activity than that of amlodipine. The most active compound (5e) had fluorine substituent (X=F).
Journal title
Research in Pharmaceutical Sciences
Serial Year
2007
Journal title
Research in Pharmaceutical Sciences
Record number
1587693
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