Author/Authors :
Hadizadeh، F. نويسنده Biotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, I.R. Iran. , , Fatehi-Hassanabad، Z. نويسنده Department of Physiology and Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, I.R.Iran. , , Fatehi-Hassanabad، M. نويسنده Department of Physiology and Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, I.R.Iran. , , Beheshtizadeh، A. نويسنده Department of Medicinal Chemistry, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, I.R Iran. , , Nabati، F. نويسنده Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, I.R.Iran. ,
Abstract :
A series of 1,4-dihydropyridine calcium channel blockers bearing 1-(4-X -benzyl)-5-imidazolyl substituent at 4 position (5a-e) (X=H, F) were synthesized and tested for antihypertensive activity in desoxycorticosterone acetate (DOCA)-induced hypertension in rats. Amlodipine was used as the standard dihydropyridine. All compounds tested showed lower antihypertensive activity than that of amlodipine. The most active compound (5e) had fluorine substituent (X=F).
