Author/Authors :
Simsek، Gulcin Guler نويسنده Kecioren Training and Research Hospital, Department of Pathology Ankara, Turkey , , Vargol، Erdem نويسنده Kecioren Training and Research Hospital, Department of Pathology Ankara, Turkey , , Simsek، Hulya نويسنده Kecioren Training and Research Hospital, Department of Pathology Ankara, Turkey ,
Abstract :
Cytomorphological changes of mitomycin C on urothelial cells may be misinterpreted
as a neoplastic process. A 60-year old male patient who was given an eight-week
course of intravesical mitomycin C due to non-invasive low grade transitional cell
carcinoma. During his follow-up care, the findings of a urine cytology exam were as
follows: nuclear enlargement of cells, wrinkled nuclear membranes, little hyperchromasia,
pleomorphism, abnormal nuclear morphology and disordered orientation of
the urothelium. Furthermore, there were eosinophils nearby the atypical cells. This
report aimed at reminding the cytomorphologic changes of mitomycin C may be misinterpreted
as carcinoma, so the presence of eosinophils is required to predict the
drug-induced changes.
