Title of article :
Mathematical analysis of competition between sensory ganglion cells for neurotrophic factor in the skin
Author/Authors :
Kohli، نويسنده , , R. and Gabriel S، نويسنده , , J.-P. and Clarke، نويسنده , , P.G.H.، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Abstract :
A model is presented of competition between sensory axons for trophic molecules (e.g. a neurotrophin such as NGF), produced in a region of skin small enough to permit their free diffusion throughout it; e.g., a touch dome, or a vibrissal follicle hair sinus. The variables specified are the number of high affinity trophic factor receptors per axon terminal and the concentration of trophic factor in the extracellular space. Previous models of this class predicted the loss of all the axons innervating the region except the one requiring least trophic factor for its maintenance, even with high rates of trophic factor production. In the present model, we have imposed upper limits to axonal growth, thereby introducing new equilibria, and we show by a global analysis using LaSalle’s theorem, and also by local analysis, that several axons can then coexist if the rate of production of trophic molecules is sufficiently high.
Keywords :
Trophic factor , axon , Coexistence , Competition , Competitive exclusion , MODELING , neurotrophin , skin
Journal title :
Mathematical Biosciences
Journal title :
Mathematical Biosciences