Title of article
On optimal delivery of combination therapy for tumors
Author/Authors
d’Onofrio، نويسنده , , Alberto and Ledzewicz، نويسنده , , Urszula and Maurer، نويسنده , , Helmut and Sch?ttler، نويسنده , , Heinz، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2009
Pages
14
From page
13
To page
26
Abstract
A mathematical model for the scheduling of angiogenic inhibitors in combination with a chemotherapeutic agent is formulated. Conditions are given that allow tumor eradication under constant infusion therapies. Then the optimal scheduling of a vessel disruptive agent in combination with a cytotoxic drug is considered as an optimal control problem. Both theoretical and numerical results on the structure of optimal controls are presented.
Keywords
Mathematical model , optimal control , Combination therapy for tumors , Anti-Angiogenesis , chemotherapy
Journal title
Mathematical Biosciences
Serial Year
2009
Journal title
Mathematical Biosciences
Record number
1589413
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