Author/Authors :
Naderi، Majid نويسنده Electrical Engineering Department, , , Miri-Moghaddam، Ebrahim نويسنده Department of Genetics, Genetics of Non-Communicable Disease Research Centre, Zahedan University of Medical Sciences, Zahedan, Iran Miri-Moghaddam, Ebrahim , Alizadeh، Shaban Ali نويسنده Department of Surgery, School of Medicine, Arak University of Medical Sciences, Arak, Iran , , Dorgalaleh، Akbar نويسنده Department of Hematology,Tehran University of Medical Sciences , Tehran, Iran Dorgalaleh, Akbar , Tabibian، Shadi نويسنده Department of Hematology, Tehran University of Medical Sciences, Tehran, Iran Tabibian, Shadi
Abstract :
Occurrence of leukemia in thalassemia major is a rare presentation. Here we report two cases of thalassemic patients, developing acute lymphoblastic leukemia. The genetic analysis revealed that, female and male patients were homozygous for IVSI-6 and IVSI-5, respectively. Two years ago the female patient presented by a high leukocyte count (154,000 µL) and male one also presented by 80,000 WBC/µL count 1 year ago. Microscopic examination of both patients revealed lymphoblasts that morphologically accommodate with ALL-L1 that were confirmed by photocytometry.
