Author/Authors :
Davari، Mohammad Hossein نويسنده Department of Occupational Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran , , Gheytasi، Hoda نويسنده PhD Student of Genetic, Translational Research Laboratory, University of Barcelona, Barcelona, Spain Gheytasi, Hoda , Golboei، S. Mohammad Hossein نويسنده Department of ENT, Birjand University of Medical Sciences, Birjand, Iran Golboei, S. Mohammad Hossein , Rezvani، Mohammad Reza نويسنده Department of Internal Medicine, Valye-Asr Hospital, Birjand University of Medical Sciences, Birjand, Iran ,
Abstract :
Alport syndrome is a genetic disorder of basement membranes caused by mutations in type IV collagen network. It was first identified by Dr. Alport in 1927. Its major clinical manifestations are included: glomerulopathy, sensory hearing loss, anterior lenticonus, and the prevalence of Alports’ gene in general population is about 1 in 5000 and the disease prevalence is 1 in 10000 [1-3]. Here we report ocular, ear and renal manifestations of Alport syndrome in 3 families that living in the east city of Iran, Birjand, and we have followed all of this family for 6 years so far.
