Title of article
A mathematical model for the first-pass dynamics of antibiotics acting on the cardiovascular system
Author/Authors
Banks، نويسنده , , H.T. and Holm، نويسنده , , Kathleen and Wanner، نويسنده , , Nathan C. and Cintrَn-Arias، نويسنده , , Ariel and Kepler، نويسنده , , Grace M. and Wetherington، نويسنده , , Jeffrey D.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2009
Pages
16
From page
959
To page
974
Abstract
We present a preliminary first-pass dynamic model for delivery of drug compounds to the lungs and heart. We use a compartmental mass-balance approach to develop a system of nonlinear differential equations for mass accumulated in the heart as a result of intravenous injection. We discuss sensitivity analysis as well as methodology for minimizing mass in the heart while maximizing mass delivered to the lungs on a first circulatory pass.
Keywords
DRUG DELIVERY , differential equations , Optimal dosing strategies , Sensitivity , Compartmental model , Circulatory system
Journal title
Mathematical and Computer Modelling
Serial Year
2009
Journal title
Mathematical and Computer Modelling
Record number
1596565
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