Chemistry of 4-fluoroglutamic acid. Part 3. Preparation of the diastereomers of 4-fluoroglutamine and 4-fluoroisoglutamine. An enzymatic access to the antipodes of 4-amino-2-fluorobutyric acid

The pure diastereomers of 4-fluoroglutamine and 4-fluoroisoglutamine were prepared from the corresponding 4-fluoroglutamic acids. Glutamic decarboxylase treatment of the acids led to chiral 2-fluoroGABA.