Title of article
Regioselective alkylation of the trifluoromethyl analog of Hagemann’s ester
Author/Authors
Legros، نويسنده , , Julien and Barhoumi-Slimi، نويسنده , , Thouraya and Crousse، نويسنده , , Beno??t and Bonnet-Delpon، نويسنده , , Danièle and El Gaied، نويسنده , , Moncef and Bégué، نويسنده , , Jean-Pierre، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
91
To page
94
Abstract
The reactivity of the enolate of the 4-carbethoxy-3-trifluoromethyl-cyclohex-2-enone (1) toward electrophiles has been studied and compared with that of the parent Hagemann’s ester. Presence of the CF3 group could allow the selective introduction of substituents at three different sites. With alkyl halides the C-2 alkylation is completely favored. High selectivity is directed to the C-4 site with ethyl chloroformate, and only O-silylation occurred with a silylated chloride.
Keywords
Trifluoromethyl , Fluorinated phenol , Cyclohexenone , Enolate alkylation , Hagemann’s ester
Journal title
Journal of Fluorine Chemistry
Serial Year
2001
Journal title
Journal of Fluorine Chemistry
Record number
1603114
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