Title of article :
A novel trifluoromethanesulfonamidophenyl-substituted quinoline derivative, GA 0113: synthesis and pharmacological profiles
Author/Authors :
Morizawa، نويسنده , , Yoshitomi and Okazoe، نويسنده , , Takashi and Wang، نويسنده , , Shu-zhong and Sasaki، نويسنده , , Jun and Ebisu، نويسنده , , Hajime and Nishikawa، نويسنده , , Masakuni and Shinyama، نويسنده , , Hiroshi، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2001
Abstract :
The trifluoromethanesulfonamidophenyl-substituted quinoline GA 0113 have been synthesized from o-nitrobenzoyl chloride via a multi-step process. GA 0113 displaced specific binding of [125I]-Sar1, Ile8-Ang II to AT1 receptors in membrane from Sf9 cells. In concious normotensive dogs, GA 0113 inhibited the Ang II-induced pressor response with ID50 of 0.032 mg/kg and dose-dependently increased plasma renin activity for 48 h.
Keywords :
(Trifluoromethylsulfonamidophenyl)quinoline , MOPAC™ , Angiotensin-II receptor antagonist , Antihypertensive drug
Journal title :
Journal of Fluorine Chemistry
Journal title :
Journal of Fluorine Chemistry
