Title of article
New fluorine-containing hypotensive preparations
Author/Authors
Yagupolskii، نويسنده , , L.M. and Maletina، نويسنده , , I.I. and Petko، نويسنده , , K.I. and Fedyuk، نويسنده , , D.V. and Handrock، نويسنده , , R. and Shavaran، نويسنده , , S.S. and Klebanov، نويسنده , , B.M. and Herzig، نويسنده , , S.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
8
From page
87
To page
94
Abstract
The synthesis and pharmacological properties of a novel type of vasorelaxant hybrid compounds are described. The investigated compounds are based on fluorinated 4-aryl-1,4-dihydropyridines (1,4-DHP), which are known calcium channel blockers, and/or from fluorinated analogues of pinacidil, an opener of ATP-sensitive potassium channels. Benzimidazole analogues of hypotensive preparation losartan with fluorine-containing substituents in positions 2 and 5, as well as at heterocyclic nitrogen atom of benzimidazole ring are discussed.
Keywords
Hypotensive preparations , Angiotensin II receptor antagonists , Benzimidazole , Calcium and potassium channels modulators , Fluorine-containing substituents
Journal title
Journal of Fluorine Chemistry
Serial Year
2001
Journal title
Journal of Fluorine Chemistry
Record number
1603168
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