Facile and regioselective synthesis of 4-fluoroalkyl-2-quinolinol

4-Fluoroalkyl-2-quinolinols were regioselectively synthesized in moderate to high yields by acid-assisted intramolecular ring-closure reaction of the corresponding N-aryl-3-oxa-polyfluoroalkanamides prepared from 2,2-dihydropolyfluoroalkanoic acids in two steps.