Author/Authors :
Irving، نويسنده , , Amy A. and Halberg، نويسنده , , Richard B. and Albrecht، نويسنده , , Dawn M. and Plum، نويسنده , , Lori A. and Krentz، نويسنده , , Kathleen J. and Clipson، نويسنده , , Linda and Drinkwater، نويسنده , , Norman and Amos-Landgraf، نويسنده , , James M. and Dove، نويسنده , , William F. and DeLuca، نويسنده , , Hector F.، نويسنده ,
Abstract :
Epidemiological studies indicate that sunlight exposure and vitamin D are each associated with a lower risk of colon cancer. The few controlled supplementation trials testing vitamin D in humans reported to date show conflicting results. We have used two genetic models of familial colon cancer, the ApcPirc/+ (Pirc) rat and the ApcMin/+ (Min) mouse, to investigate the effect of 25-hydroxyvitamin D3 [25(OH)D3] and two analogs of vitamin D hormone on colonic tumors. Longitudinal endoscopic monitoring allowed us to test the efficacy of these compounds in preventing newly arising colonic tumors and in affecting established colonic tumors. 25(OH)D3 and two analogs of vitamin D hormone each failed to reduce tumor multiplicities or alter the growth patterns of colonic tumors in the Pirc rat or the Min mouse.
