Nucleophilic fluorination of amino alcohols and diols using Deoxofluor

Various fluorinated chiral compounds were synthesized using bis(2-methoxyethyl)aminosulfur trifluoride (Deoxofluor) as a nucleophilic fluorinating reagent. Reactions of Deoxofluor (1) with amino alcohols (2a–d) and diols (2e–g) in methylene chloride at room temperature led to the formation of the corresponding fluoro derivatives (3a–g) in good yields.