Uncatalyzed Meerwein–Ponndorf–Verley reduction of trifluoromethyl carbonyl compounds by high-temperature secondary alcohols

Noncatalytic Meerwein–Ponndorf–Verley (MPV) reduction of hexafluoroacetone and methyl ester of trifluoropyruvic acid into hexafluoroisopropanol (HFIP) and trifluorolactic esters, respectively can be achieved by heating with secondary alcohols at 210–250 °C without any catalyst.