Title of article
A general method of halogenation for synthesis of α-halodifluoromethyl ketones and [18F]-labeled trifluoromethyl ketones
Author/Authors
Prakash، نويسنده , , G.K.Surya and Hu، نويسنده , , Jinbo and Alauddin، نويسنده , , Mian M and Conti، نويسنده , , Peter S and Olah، نويسنده , , George A، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
5
From page
239
To page
243
Abstract
A convenient general method of halogenations suitable for synthesis of α-halodifluoromethyl ketones is reported. Reaction of 2,2-difluoro-1-aryl-1-trimethylsiloxyethenes (difluoro silyl enol ethers) (2a–e) with halogens at low temperature (−30 to −78 °C) produced a high yield of α-halodifluoromethyl ketones (1a–j). This one-step simple method can be highly useful for synthesis of [18F]-labeled α-trifluoromethyl ketones.
Keywords
Halogenation , Electrophilic fluorination , Fluorine-18
Journal title
Journal of Fluorine Chemistry
Serial Year
2003
Journal title
Journal of Fluorine Chemistry
Record number
1607562
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