Regiospecific synthesis of symmetrical (1E,3E) 2,3-difluoro-1,4-diphenyl-buta-1,3-dienes via palladium-catalyzed cross-coupling of (Z) 2-bromo-2-fluoroethenylbenzenes in presence of bis(pinacolato)diboron

The cross-coupling reaction of (Z) 1-bromo-1-fluoroalkenes catalyzed by PdCl2(PPh3)2-2PPh3 (3%) and CsF in Tetrahydrofuran (THF) in presence of bis(pinacolato)diboron led to (1E,3E) 2,3-difluoro-1,4-disubstituted-buta-1,3-dienes in high yields.