• Title of article

    Synthesis of trifluoromethylated pyrazoles from trifluoromethylenaminones and monosubstituted hydrazines

  • Author/Authors

    Touzot، نويسنده , , Aline and Soufyane، نويسنده , , Mustapha and Berber، نويسنده , , Hatice and Toupet، نويسنده , , Lo??c and Mirand، نويسنده , , Catherine، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2004
  • Pages
    6
  • From page
    1299
  • To page
    1304
  • Abstract
    Cyclocondensation of monosubstituted hydrazines 2a–c with trifluoromethylenaminones 1a–c afforded 3-CF3 and (or) 5-CF3 pyrazoles 3–6. Addition of N-methylhydrazine to enaminone led to 3-CF3 pyrazole as the major product, whereas phenylhydrazine gave regiospecific formation of 5-CF3 pyrazole. ural assignment of regioisomers is based on 13C NMR chemical shifts, long-range carbon–fluorine and hydrogen–fluorine coupling constants and 1H–1H NOE. razole 4ac was characterized by X-ray diffraction analysis.
  • Keywords
    Trifluoromethyl-1H-pyrazoles , ?-Enaminotrifluoromethylketones , Methylhydrazine , Phenylhydrazine
  • Journal title
    Journal of Fluorine Chemistry
  • Serial Year
    2004
  • Journal title
    Journal of Fluorine Chemistry
  • Record number

    1608404