Synthesis and dissolved hyperpolarized xenon NMR studies of sucrose octaoleate-F104

Sucrose octaoleate-F104 has been prepared from sucrose and the acid chloride of RF-oleic acid-F13 in 86% yield using dry pyridine as solvent. The product has been characterized by MALDI-TOF mass spectrometry and 1H and 13C NMR methods. Some preliminary 129Xe NMR results are included using hyperpolarized xenon gas dissolved in an aqueous emulsion containing egg yolk phospholipid and the octaester. The in vitro spin lattice relaxation time of dissolved xenon as well as the 129Xe chemical shift suggest that highly fluorinated sucrose polyesters (HFSPE’s) may be promising molecules for use as part of in vivo delivery systems for hyperpolarized xenon.