Title of article :
First enantioselective reductive amination of α-fluoroenones
Author/Authors :
Dutheuil، نويسنده , , Guillaume and Bailly، نويسنده , , Laetitia and Couve-Bonnaire، نويسنده , , Samuel and Pannecoucke، نويسنده , , Xavier، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2007
Abstract :
From α-fluoroenones 2, a synthesis of (E) ketone oxime O-alkyl ethers 5 is reported with good to excellent yields. Then the first enantioselective reduction of these ketimines, via oxazaborolidine, is described with moderate to good enantiomeric excesses, leading to valuable chiral fluoroallylic amines 1.
Keywords :
Fluoroalkene , Fluoroenone , Ketone oxime ether , oxazaborolidine , Enantioselective reductive amination
Journal title :
Journal of Fluorine Chemistry
Journal title :
Journal of Fluorine Chemistry
