Three-fold polyfluoroalkylated amines and isocyanates based on tris(hydroxymethyl)aminomethane (TRIS)

Three-fold polyfluoroalkylated amines were prepared from tris(hydroxymethyl)aminomethane (TRIS) in five steps including perfluoroalkyl iodide addition to the corresponding allyl derivative, reduction of C–I bond and deprotection of the amino group. They can be easily converted to the corresponding isocyanates.