Title of article
Nucleophilic (phenylsulfinyl)difluoromethylation of carbonyl compounds with difluoromethyl phenyl sulfoxide
Author/Authors
Zhu، نويسنده , , Lingui and Li، نويسنده , , Ya-Ru Ni، نويسنده , , Chuanfa and Hu، نويسنده , , Jinbo and Beier، نويسنده , , Petr and Wang، نويسنده , , Ying and Surya Prakash، نويسنده , , G.K. and Olah، نويسنده , , George A.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
7
From page
1241
To page
1247
Abstract
We have successfully achieved nucleophilic (phenylsulfinyl)difluoromethylation of both enolizable and non-enolizable aldehydes and ketones by using difluoromethyl phenyl sulfone (1) as the fluoroalkylating agent. Although the chemical yields of the reactions are good to excellent, the observed diastereoselectivity is poor (dr = 1:1.04–2.03). The present synthetic methodology provides a convenient alternative for the preparation of α-(phenylsulfinyl)difluoromethylated carbinols that were previously synthesized via a two-step procedure.
Keywords
Difluoromethyl sulfoxide , nucleophilic addition , (Phenylsulfinyl)difluoromethylation
Journal title
Journal of Fluorine Chemistry
Serial Year
2007
Journal title
Journal of Fluorine Chemistry
Record number
1609902
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