Title of article
Nucleophilic trifluoromethylation of aryl halides with methyl trifluoroacetate
Author/Authors
Langlois، نويسنده , , Bernard R. and Roques، نويسنده , , Nicolas، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
8
From page
1318
To page
1325
Abstract
When associated with an alkaline halide, such as cesium fluoride or cesium chloride, and Cu(I) species, methyl trifluoroacetate (MTFA) constitutes a valuable trifluoromethylating agent for substituting aromatic (or heteroaromatic) iodides and bromides. The reaction can be carried out in DMF at 180 °C or, better, in sulfolane which allows he reaction to proceed at a lower temperature (from 140 °C).
Keywords
Benzotrifluorides , Methyl trifluoroacetate , Alkaline chlorides , Aromatic substitution , (Trifluoromethyl)arenes , Alkaline fluorides , trifluoromethylation
Journal title
Journal of Fluorine Chemistry
Serial Year
2007
Journal title
Journal of Fluorine Chemistry
Record number
1609923
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