Continuous flow glassware reactors for the laboratory: Synthesis of 2-alkoxy-4-aminotrifluoropyridine derivatives from pentafluoropyridine

Simple, general use continuous flow glassware reactors that are constructed by standard glass blowing techniques have been designed and used for various nucleophilic aromatic substitution reactions. The glassware flow reactors, consisting of a reaction channel that is 0.5 mm in diameter and may possess a range of inlet and outlet ports, provide the opportunity for research scientists to use inexpensive, conveniently operated continuous flow methodology in the laboratory environment. A short series of 2-alkoxy-4-aminotrifluoropyridine derivatives was prepared from pentafluoropyridine in a single continuous flow process by sequential nucleophilic aromatic substitution.