Author/Authors :
Kirij، نويسنده , , Nataliya V. and Babadzhanova، نويسنده , , Lesya A. and Movchun، نويسنده , , Valeria N. and Yagupolskii، نويسنده , , Yurii L. and Tyrra، نويسنده , , Wieland and Naumann، نويسنده , , Dieter and Fischer، نويسنده , , Hendrik T.M. and Scherer، نويسنده , , Harald، نويسنده ,
Abstract :
The reactions of non-activated aldimines with trimethyl(trifluoromethyl)silane and 1 equiv. of tetramethylammonium fluoride proceed via the formation of tetramethylammonium amides which were identified by low-temperature 19F NMR experiments. Consecutive reactions of the salts formed in situ with electrophiles yielded trifluoromethylated amines. Fluoride elimination is observed in the absence of electrophilic substrates leading to the formation of difluoromethylated ketimines.
Keywords :
Amines , Aldimines , Alkylation , Silylation , trifluoromethylation
