Title of article
Trifluoromethylation of non-activated aldimines with trimethyl(trifluoromethyl)silane in the presence of tetramethylammonium fluoride: A closer look into the reaction route
Author/Authors
Kirij، نويسنده , , Nataliya V. and Babadzhanova، نويسنده , , Lesya A. and Movchun، نويسنده , , Valeria N. and Yagupolskii، نويسنده , , Yurii L. and Tyrra، نويسنده , , Wieland and Naumann، نويسنده , , Dieter and Fischer، نويسنده , , Hendrik T.M. and Scherer، نويسنده , , Harald، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
8
From page
14
To page
21
Abstract
The reactions of non-activated aldimines with trimethyl(trifluoromethyl)silane and 1 equiv. of tetramethylammonium fluoride proceed via the formation of tetramethylammonium amides which were identified by low-temperature 19F NMR experiments. Consecutive reactions of the salts formed in situ with electrophiles yielded trifluoromethylated amines. Fluoride elimination is observed in the absence of electrophilic substrates leading to the formation of difluoromethylated ketimines.
Keywords
Amines , Aldimines , Alkylation , Silylation , trifluoromethylation
Journal title
Journal of Fluorine Chemistry
Serial Year
2008
Journal title
Journal of Fluorine Chemistry
Record number
1609976
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