Synthesis and structure of trifluoromethylated arylhydrazones formed from coupling of 4-(dimethylamino)-1,1,1-trifluorobut-3-en-2-one with diazonium salts

A series of trifluoromethyl-containing arylhydrazones were prepared via a direct azo-coupling of (E)-4-(dimethylamino)-1,1,1-trifluorobut-3-en-2-one (1) with different aromatic diazonium salts. Furthermore, we also discussed the non-covalent interactions existing in the crystal structure of compound (E)-4,4,4-trifluoro-2-(2-(4-iodophenyl)hydrazono)-3-oxobutanal (3c) by the X-ray diffraction analysis.