Title of article :
Copper catalyzed 1,3-dipolar cycloaddition reaction of azides with N-(2-trifluoroacetylaryl)propargylamines: A mild entry to novel 1,4-disubstituted-[1,2,3]-triazole derivatives
Author/Authors :
Lamarque، نويسنده , , Jean-Florent and Lamarque، نويسنده , , Christophe and Lassara، نويسنده , , Sandrine and Médebielle، نويسنده , , Maurice and Molette، نويسنده , , Jérome and David، نويسنده , , Emilie and Pellet-Rostaing، نويسنده , , Stéphane and Lemaire، نويسنده , , Marc and Okada، نويسنده , , Etsuji and Shibata، نويسنده , , Dai and Pilet، نويسنده , , Guillaume، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
The synthesis of N-(2-trifluoroacetylaryl)propargylamines 10–14 and 17 is presented. The copper(I) catalyzed cycloaddition reaction of these propargylamines (dipolarophiles) with a series of azides (1,3-dipoles) 18–20, 21 and 24 was found to proceed smoothly in dimethylsulfoxide at room temperature, to furnish the corresponding 1,4-disubstituted-[1,2,3]triazole derivatives 26–36 in moderate to good yields.
Keywords :
Propargylamines , Azides , Triazole , SNAr , cycloaddition
Journal title :
Journal of Fluorine Chemistry
Journal title :
Journal of Fluorine Chemistry
