Title of article
Synthesis and biological evaluation of fluorinated acyclothionucleosides
Author/Authors
Jean-Philippe and Gouault-Bironneau، نويسنده , , Sonia and Sène، نويسنده , , Aboubacary and Catel، نويسنده , , Jean-Marie and Lequeux، نويسنده , , Thierry، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
848
To page
851
Abstract
The discovery of thio- and fluoro-nucleosides as antiviral or anticancer agents prompts us to explore the synthesis of acyclic analogues. In this paper is reported the preparation of acyclothionucleosides by the alkylation of nucleic bases with difluorothio-esters and -alcohols. Compounds structurally close to known antiviral agents were tested towards a large variety of viruses.
Keywords
Acyclothionucleoside , Fluorosulfide , Nucleic base
Journal title
Journal of Fluorine Chemistry
Serial Year
2008
Journal title
Journal of Fluorine Chemistry
Record number
1610225
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