Title of article
Activation of hydrocinnamic acids with pentafluorophenol versus pentafluorothiophenol: Reactivity towards hexylamine
Author/Authors
Roleira، نويسنده , , Fernanda M.F. and Borges، نويسنده , , Fernanda and Andrade، نويسنده , , Lourdes C.R. and Paixمo، نويسنده , , José A. and Almeida، نويسنده , , Maria J.M. and Carvalho، نويسنده , , Rui A. and Tavares da Silva، نويسنده , , Elisiلrio J.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2009
Pages
6
From page
169
To page
174
Abstract
In this work we describe and compare the synthesis of four new hexylamides of hydrocinnamic acids, namely hexylamide of hydrocinnamic, 3,4-dimethoxyhydrocinnamic, 4-hydroxy-3-methoxyhydrocinnamic and 3,4-dihydroxyhydrocinnamic acids via pentafluorophenyl esters (PFPEs) versus pentafluorophenyl thioesters (PFPTs) intermediates. It was found that the PFPE are the best intermediates for this kind of synthesis giving reactions with less by products, easier work-up, higher overall yields and with the best reactivity towards hexylamine. The X-ray structures of two PFPE are also reported.
Keywords
Hydrocinnamic acids , Pentafluorophenyl esters , Pentafluorophenyl thioesters , Hexylamides , Phenols , X-ray structures
Journal title
Journal of Fluorine Chemistry
Serial Year
2009
Journal title
Journal of Fluorine Chemistry
Record number
1610397
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