Title of article :
Novel efficient synthesis of β-fluoro-β-(trifluoromethyl)styrenes
Author/Authors :
Goldberg، نويسنده , , Aleksey A. and Muzalevskiy، نويسنده , , Vasiliy M. and Shastin، نويسنده , , Aleksey V. and Balenkova، نويسنده , , Elisabeth S. and Nenajdenko، نويسنده , , Valentine G.، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2010
Abstract :
CF3CFBr2 was employed in catalytic olefination reactions of aromatic aldehydes. In situ prepared hydrazones of aldehydes were transformed to β-fluoro-β-(trifluoromethyl)styrenes by reaction with CF3CFBr2 under CuCl catalysis. Based on this reaction, a novel stereoselective approach towards β-fluoro-β-(trifluoromethyl)styrenes was elaborated. Nucleophilic vinylic substitution of fluorine by secondary amines, thiolates and alkoxides in β-fluoro-β-(trifluoromethyl)styrenes was also tested.
Keywords :
1-Dibromotetrafluoroethane , 1 , Fluorinated alkenes , Olefination , Aromatic aldehydes , Copper catalysis
Journal title :
Journal of Fluorine Chemistry
Journal title :
Journal of Fluorine Chemistry
