Title of article :
N-Fluoro-(3,5-di-tert-butyl-4-methoxy)benzenesulfonimide (NFBSI): A sterically demanding electrophilic fluorinating reagent for enantioselective fluorination
Author/Authors :
Yasui، نويسنده , , Hiroyuki and Yamamoto، نويسنده , , Takeshi and Ishimaru، نويسنده , , Takehisa and Fukuzumi، نويسنده , , Takeo and Tokunaga، نويسنده , , Etsuko and Akikazu، نويسنده , , Kakehi and Shiro، نويسنده , , Motoo and Shibata، نويسنده , , Norio، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2011
Abstract :
We disclose here a novel electrophilic fluorinating reagent, N-fluoro-(3,5-di-tert-butyl-4-methoxy)benzenesulfonimide (NFBSI) as a sterically demanding analogue of popular fluorinating reagent, N-fluorobenzenesulfonmide (NFSI). NFBSI improves the enantioselectivity of the products as much as 18% for the cinchona alkaloid-catalyzed enantioselective fluorination of silylenol ether compared to the use of NFSI.
Keywords :
Catalytic , enantioselective , Synthesis , Electrophilic fluorination , Fluorinating reagent
Journal title :
Journal of Fluorine Chemistry
Journal title :
Journal of Fluorine Chemistry
