Title of article
Selective trifluoromethylation and alkynylation of tetrahydroisoquinolines using visible light irradiation by Rose Bengal
Author/Authors
Fu، نويسنده , , Weijun and Guo، نويسنده , , Wenbo and Zou، نويسنده , , Guanglong and Xu، نويسنده , , Chen، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2012
Pages
7
From page
88
To page
94
Abstract
A convenient and efficient method for oxidative coupling of tetrahydroisoquinoline derivatives with trimethyl(trifluoromethyl)silane and terminal alkynes to 1-trifluoromethylated or 1-alkynylated tetrahydroisoquinolines via CH activation was developed using visible light irradiation. The protocol uses Rose Bengal as the catalyst, air as terminal oxidant, and the trifluoromethylation or alkynylation was selectively performed at the α-position of nitrogen under extremely mild conditions.
Keywords
trifluoromethylation , Alkynylation , Trimethyl(trifluoromethyl)silane , Tetrahydroisoquinoline , Visible light , Photooxidation
Journal title
Journal of Fluorine Chemistry
Serial Year
2012
Journal title
Journal of Fluorine Chemistry
Record number
1611829
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