Reactions of 6-(tri- and 6-(difluoromethyl))comanic acids and their ethyl esters with aniline and its 2-substituted derivatives

Reactions of 6-(tri- and 6-(difluoromethyl))comanic acids with aniline, o-phenylenediamine and o-aminophenol were investigated. RF-containing derivatives of 4-pyridones, benzodiazepines and quinoxalinones were synthesized. Electrophilic properties of 6-(trifluoromethyl)comanic acid were evaluated.