Title of article :
Synthesis of novel fluorine- and iodine-containing [1,2,4]triazolo[3,4-b][1,3]thiazines based 3-(alkenylthio)-5-(trifluoromethyl)-4H-1,2,4-triazole-3-thiols
Author/Authors :
Il’inykh، نويسنده , , Elena S. and Kim، نويسنده , , Dmitry G. and Kodess، نويسنده , , Mikhail I. and Matochkina، نويسنده , , Evgeniya G. and Slepukhin، نويسنده , , Pavel A.، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2013
Abstract :
In this paper we report the synthesis of novel S-alkenyl derivatives of 5-(trifluoromethyl)-4H-1,2,4-triazole-3-thiol via alkenation reaction with different alkenyl halides. Reaction between the resulting S-alkenation products and iodine proceeds regiospecifically to give new fused fluorine- and iodine-containing [1,2,4]triazolo[3,4-b][1,3]thiazine heterocyclic systems. The structure of synthesized compounds was confirmed by mass spectra, IR, 1H, 13C and 19F NMR spectroscopy including 2D 1H–13C HSQC, 1H–1H COSY, 1H–13C HMBC correlations, elemental analysis and single-crystal X-ray diffraction study.
Keywords :
iodination , 1 , 4-triazole-3-thiol , S-alkenation , Halogenation , 2 , 4-b]1 , 3]thiazine heterocyclic systems , 2
Journal title :
Journal of Fluorine Chemistry
Journal title :
Journal of Fluorine Chemistry