Alkynes XF2CCCP(O)(OR)2: Synthesis and reactivity

Fluoroalkyl alkynylphosphonates are of high stability, and mostly colorless liquid compounds, which are showing constantly growing interest due to their ability to introduce, in one pot, both of these functional groups into one molecule. The fact that they are not commercially available is reflected in the limited number of reactions of such acetylenes. However, the easy and straightforward synthetic methodology to produce the titled compounds for the development of novel compounds with altered chemical, biological and physical properties is making them to go out of the shadow. Therefore, synthesis and reactivity toward cyclization and addition reactions are reviewed herein.