Title of article :
Synthesis of 1-aryl-4-tosyl-5-(trifluoromethyl)-1H-imidazoles
Author/Authors :
V. A. Bunev، نويسنده , , Alexander S. and Vasiliev، نويسنده , , Maksim A. and Statsyuk، نويسنده , , Vladimir E. and Ostapenko، نويسنده , , Gennady I. and Peregudov، نويسنده , , Alexander S.، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2014
Abstract :
A new synthetic protocol for the synthesis of 1,4,5-trisubstituted imidazoles containing trifluoromethyl group has been developed using van Leusen reaction, which incorporates two-component condensation reaction trifluoroacetimidoyl chlorides with tosylmethylisocyanide. This protocol provides a novel and improved method for obtaining trifluoromethyl containing 1,4,5-trisubstituted imidazoles in good yields.
Keywords :
van Leusen reaction , Trifluoromethyl azoles , imidazoles , Trifluoroacetimidoyl halides , Isocyanides
Journal title :
Journal of Fluorine Chemistry
Journal title :
Journal of Fluorine Chemistry
