Chemical modification of chitosan 11: chitosan–dendrimer hybrid as a tree like molecule

Tetraethylene glycol was modified by two different approaches to synthesize the scaffold of dendrimer. Poly(amido amine) (PAMAM) dendrimers (G=1–3) having tetraethylene glycol spacer were prepared and attached to chitosan by reductive N-alkylation. On chitosan molecules, the degree of substitution of dendrimers was 0.03–0.18. Sialic acid residue bound PAMAM dendrimers of each generation were successfully attached to chitosan.