Author/Authors :
Zhou، نويسنده , , Jia-Hong and Xia، نويسنده , , Sheng-Qin and Chen، نويسنده , , Jing-Rong and Wang، نويسنده , , Xue-Song and Zhang، نويسنده , , Bao-Wen and Zhang، نويسنده , , Hui-Jun and Zou، نويسنده , , Ping and Ai، نويسنده , , Xi Cheng and Zhang، نويسنده , , Jian-Ping، نويسنده ,
Abstract :
The surface binding association between a positively charged polymeric complex of hypocrellin A (HA) with La3+ (La3+-HA) and calf thymus DNA (CT DNA) was confirmed by ESR and laser flash photolysis techniques along with UV-Vis absorption and fluorescence emission spectra. This surface binding, in cooperation with the longer triplet excited state lifetime of La3+-HA, gave rise to a stronger photodamage of CT DNA both in aerobic and anaerobic conditions by La3+-HA compared with HA.
Keywords :
Surface binding , Hypocrellin A , Lanthanum ion complex , Photodamage of DNA
