Title of article
Polycyclic compounds by sunlight exposure of the drug rosuvastatin in water
Author/Authors
Astarita، نويسنده , , Anna and DellaGreca، نويسنده , , Marina and Iesce، نويسنده , , Maria Rosaria and Montanaro، نويسنده , , Sara and Previtera، نويسنده , , Lucio and Temussi، نويسنده , , Fabio، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
6
From page
263
To page
268
Abstract
Irradiation of rosuvastatin in water by sunlight or UV lamp (Pyrex) affords cyclic compounds. The main photo-induced reaction is cyclization of the drug to give diastereomeric dihydrobenzoquinazolines. Products derived from side-chain loss were also isolated in the irradiation mixture, and characterized as dihydrobenzoquinazoline and benzoquinazoline derivatives by spectroscopic means. Photoproducts structure elucidation and mechanistic hypothesis are reported.
Keywords
Photocyclization , Photoxidation , Rosuvastatin , Benzoquinazolines , Dihydrobenzoquinazolines
Journal title
Journal of Photochemistry and Photobiology:A:Chemistry
Serial Year
2007
Journal title
Journal of Photochemistry and Photobiology:A:Chemistry
Record number
1615391
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