A study on the supramolecular structure of inclusion complex of β-cyclodextrin with prazosin hydrochloride

The supramolecular structure of the inclusion complex of β-cyclodextrin (βCD) with prazosin hydrochloride (PRH) has been investigated. The 1:1 stoichiometry of complexation was achieved by phase solubility study and the inclusion complex with 1:1 molar ratio was prepared by co-precipitation method. DSC analysis confirmed that the inclusion complex was formed. XRD patterns of βCD and inclusion complex indicated that the structures of them belonged to the channel-type packing structure, and the axial structure period was two times the depth of βCD torus. The fragment of PRH molecule which entrapped into the βCD cavity was proposed on the basis of Fourier transformation-infrared analysis and the predicted model indicated that the furan ring and the conjunctive carbonyl group of PRH molecule were inserted into the βCD cavity.