Cellulose/poly(ethylene glycol) blend and its controllable drug release behaviors in vitro

By preparation of a cellulose/poly(ethylene glycol)(PEG) blend and using DSC to analyze its thermal properties, this paper reported that such polymer blend might be applied as a drug carrier to provide novel drug release behavior. According to DSC analysis, such polymer blend has a controlled phase change property, and changing the ratio of these two polymers capably controls this property. For detailed drug release, this temperature response phenomenon was found visibly to depress drug released from blend that absolutely different than that of other temperatures. The pH response of this polymer blend has been found only suitable for releasing drug in an acidic media, e.g. pH about 4, multi-pulse type and forbidden in a base liquor.