Synthesis and anti-hyperlipidemic activity of a novel starch piperinic ester

A novel starch piperinic ester (SPE) with anti-hyperlipidemia activity was synthesized by coupling a carboxylic group of piperic acid and a hydroxyl group on the backbone of starch. The synthetic process includes three steps. Firstly, piperic acid was obtained by hydrolyzing Piperine that was extracted from seeds of Piper longum L. (traditional medicine of Mongolian). Then, piperic acid was reacted with Carbonyldiimidazole (CDI) in DMSO under N2 at 70 °C for 4 h. Finally, starch piperinic ester was obtained by the reaction of activated piperic acid with water soluble starch at 80 °C under N2 for 24 h. The structure of the novel copolymer was characterized by FTIR, 13C NMR and 1H NMR. Anti-hyperlipidemic activity of SPE was assayed by pharmacological testes and the results indicated that the SPE had high anti-hyperlipidemic activity and would be one kind of new potential candidate of anti-hyperlipidemia pro-drug.