Title of article
Chitin oligosaccharides inhibit oxidative stress in live cells
Author/Authors
Ngo، نويسنده , , Dai-Nghiep and Kim، نويسنده , , Moon-Moo and Kim، نويسنده , , Se-Kwon، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
7
From page
228
To page
234
Abstract
The aim of this research is to identify the cellular antioxidant effects of chitin oligosaccharides (NA-COS; Mw 229.21–593.12 Da) produced by acidic hydrolysis of crab chitin. The inhibitory effect of NA-COS on myeloperoxidase (MPO) activity in human myeloid cells (HL-60) and oxidation of DNA and protein in mouse macrophages (Raw 264.7) were identified. Furthermore, their direct radical scavenging effect by 2′,7′-dichlorofluorescein (DCF) intensity and intracellular glutathione (GSH) level were significantly increased in a time dependent manner, respectively. These results suggest that NA-COS act as a potent antioxidant in live cells.
Keywords
Chitin oligosaccharides (NA-COS) , antioxidant , Free radical scavenging , Reactive oxygen species , glutathione
Journal title
CARBOHYDRATE POLYMERS
Serial Year
2008
Journal title
CARBOHYDRATE POLYMERS
Record number
1617526
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