Title of article :
Analysis of chemical composition, structure of Grifola frondosa polysaccharides and its effect on skin TNF-α levels, lgG content, T lymphocytes rate and caspase-3 mRNA
Author/Authors :
Xu، نويسنده , , Hui and Liu، نويسنده , , Jiang-hang and Shen، نويسنده , , Zheng-yu and Fei، نويسنده , , Ye and Chen، نويسنده , , Xiang-Dong، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2010
Pages :
5
From page :
687
To page :
691
Abstract :
The polysaccharide was extracted from Grifola frondosa mushroom. The chemical composition of G. frondosa polysaccharide was analyzed by the gas chromatography–mass spectroscopy (GC–MS). The G. frondosa polysaccharide was found to consist of glucose, mannose and galactose with a molar ratio of 6.5:1:2.6. The structure of G. frondosa polysaccharide was characterized by infrared (IR) spectrum, 1D NMR and 2D NMR spectroscopy. The absorption peaks of 1415 cm−1, 1154 cm−1 and 851 cm−1 suggested the polysaccharide consisted of pyranoside. It was found that G. frondosa polysaccharide was a heteropolysaccharide consisting of the repeating disaccharide unit. Comparing control rats, G. frondosa polysaccharide treatment markedly enhanced skin TNF-α levels, reduced lgG content, T lymphocytes rate and caspase-3 mRNA expression in group 2 rats. Administration of G. frondosa polysaccharide significantly reduced skin levels of TNF-α, increased lgG content, T lymphocytes rate and caspase-3 mRNA expression in groups 3 and 4 rats. In conclusion, G. frondosa polysaccharides are beneficial for those with skin diseases.
Keywords :
IR , Grifola frondosa polysaccharide , NMR , Skin diseases , GC–MS
Journal title :
CARBOHYDRATE POLYMERS
Serial Year :
2010
Journal title :
CARBOHYDRATE POLYMERS
Record number :
1622097
Link To Document :
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