Crassicauline A/β-cyclodextrin host–guest system: Preparation, characterization, inclusion mode, solubilization and stability

The inclusion complexation behavior, characterization and binding ability of crassicauline A (CLA) with β-cyclodextrin (β-CD) has been investigated in both solution and the solid state by means of UV–vis spectroscopy, FT-IR, 1H and 2D NMR, XRD, SEM and DSC. The results showed that the water solubility and thermal stability of CLA were obviously increased in the inclusion complex with β-CD. This satisfactory water solubility and high stability of the CLA/β-CD complex will be potentially useful for its application as herbal medicine or healthcare products.