Title of article
O-Carboxymethyl chitosan nanoparticles for metformin delivery to pancreatic cancer cells
Author/Authors
Snima، نويسنده , , K.S. and Jayakumar، نويسنده , , R. and Unnikrishnan، نويسنده , , A.G. and Nair، نويسنده , , Shantikumar. V. and Lakshmanan، نويسنده , , Vinoth-Kumar، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2012
Pages
5
From page
1003
To page
1007
Abstract
In this work we developed metformin loaded O-carboxymethyl chitosan (O-CMC) nanoparticles (NPs) by ionic-gelation method. The prepared NPs of 240 ± 50 nm size with spherical morphology exhibited a pH sensitive release of metformin in vitro. Cytotoxicity studies showed that the drug-incorporated NPs induced significant toxicity on pancreatic cancer cells (MiaPaCa-2) compared to normal cells (L929). Metformin loaded NPs exhibited nonspecific internalization by normal and pancreatic cancer cells; however metformin released from the NPs induced preferential toxicity on pancreatic cancer cells. Our preliminary studies suggested that such a novel approach could possibly overcome the current limitations of metformin in its clinical application against pancreatic cancer.
Keywords
DRUG DELIVERY , Metformin , O- chitosan , pancreatic cancer , Nanoparticles
Journal title
CARBOHYDRATE POLYMERS
Serial Year
2012
Journal title
CARBOHYDRATE POLYMERS
Record number
1623772
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